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Transdermal Iontophoresis of Hydromorphone Hydrochloride by Maansi Kumar (Paperback, 2009)

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About this product

Product Information

The effect of various electronic and formulation variables on the in vitro permeation profiles and rate of hydromorphone across freshly-excised full-thickness hairless rat skin were investigated. The stability of the hydromorphone hydrochloride solution to the skin enzymes was also determined. Furthermore, the effects of current strength and drug concentration on the pharmacokinetics and pharmacodynamics of hydromorphone were evaluated in vivo in hairless rats. Current was supplied by Phoresor IITM and the Trans Q1 GS patches were used in the in vivo studies. Results showed that by manipulating the electronic and formulation variables the transdermal iontophoretic delivery of hydromorphone hydrochloride can be controlled, and the possibility of obtaining therapeutically effective hydromorphone concentrations for the management of cancer-related pain is feasible by transdermal iontophoresis.

Product Identifiers

Publisher
LAP
ISBN-13
9783838306179
eBay Product ID (ePID)
93371963

Product Key Features

Author
Maansi Kumar
Publication Name
Transdermal Iontophoresis of Hydromorphone Hydrochloride
Format
Paperback
Language
English
Subject
Biology
Publication Year
2009
Type
Textbook
Number of Pages
168 Pages

Dimensions

Item Height
229mm
Item Width
152mm
Item Weight
254g

Additional Product Features

Title_Author
Maansi Kumar
Country/Region of Manufacture
Germany

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